Dikšić Mirko

Corresponding members II. Department of Mathematical, Physical and Chemical Sciences
Dikšić Mirko

Date of birth:

  • 1942

Place of birth:

  • Cvetković (Jastrebarsko)


Dikšić Mirko

Corresponding members II. Department of Mathematical, Physical and Chemical Sciences

Academic titles:

  • professor emeritus

Membership in the Academy:

  • correspondent member – Department of Mathematical, Phisical and Chemical Sciences (5/12/2016. – …)

Curriculum Vitae

Mirko Dikšić, a Croatian biochemist, was born in 1942 in Cvetković near Jastrebarsko. He studied chemistry at the Faculty of Science, University of Zagreb, where he graduated in 1966 and began his scientific career at the Ruđer Bošković Institute as an assistant in the Laboratory for Nuclear Chemistry of the Department of Physical Chemistry. Dikšić continued his education at the postgraduate study of chemistry at the Faculty of Science, University of Zagreb, and achieved a master’s degree in science in 1968 and two years later received his Doctorate. After that, from 1971-1973  works as a post-Doctoral student in the Department of Chemistry at McGill University, Montreal, Canada.

Mirko Dikšić is a Croatian and Canadian citizen, and for the most part he achieved his extremely successful scientific career working at McGill University until 2010. when he retires as Professor Emeritus of this famous university.

Mirko Dikšić is a scientist who has successfully used his abundant experience in basic sciences and applied that knowledge to neurobiological and neuropharmacological research.

After joining the Montreal Neurological Institute in 1979 Mirko Dikšić, along with a research group, devised and set up the first medical cyclotron facility in Canada designed exclusively for medical research. The cyclotron was opened in 1981, and was used very successfully for research until 1991, when it was replaced with a new and improved machine still used today. He made a substantial contribution to the development of the methods for the synthesis of radioactive labeled compounds used medical research. At the same time, Mirko Dikšić established a radiochemical laboratory to prepare biologically active molecules marked with the short living 18F md 11C radioisotopes. These labeled molecules have been used in investigations of processes in the human CNS in vivo using PET.

Mirko Dikšić made a significant contribution to oncological brain research. Soon after the installation of the cyclotron, one of the first radioactively labeled radiopharmaceuticals was a drug named Carmustine (1,3 di-chloroethylen nitrosourea, BCNU), that is often used in the treatment of brain tumors. Mirko Dikšić was first to demonstrate that the effects of BCNU depend on its routes of administration. Using PET studies, it was determined that 11C-BCNU following intra-arterial administration accumulated in brain tumors 50% more than after intravenous administration.
A great deal of Mirko Dikšić‘s scientific work is connected to studies in the control of the synthesis rate of the neurotransmitter (serotonin) in the CNS. It is assumed that alterations of the serotonergic system in the brain are related to psychiatric disorders such as depression, schizophrenia, eating disorders and substance abuse disorders (alcoholism).
At the end of the 20th Century Mirko Dikšić, together with associates from both Japan and Croatia, investigated the effects of psychotropic drugs that produce their effects via the serotonergic system, on the rate of serotonin synthesis. It has been shown that the anorectic drug fenfluramine and the antidepressant drug fluoxetine (better known as ‘Prozac’) increase the rate of serotonin synthesis in nerve terminal regions (cortices, striatum, hippocampus), while they simultaneously decrease the rate of serotonin synthesis in the regions of the serotonergic cell bodies. Furthermore, the effect seems to be different after acute and chronic administration. The obtained data indicated that alterations of serotonergic receptors activity may be one of the factors involved in the regulation of serotonin synthesis.

Mirko Dikšić is one of the first scientists to determine the rate of serotonin synthesis in the human brain in vivo, using 11C-alpha-methyltryptophan synthesized in his laboratory. The most significant contribution of this study was the finding that the rate of serotonin synthesis in healthy male and female brains is differently affected by mild ‘stress’ produced by lowering body tryptophan.